Ester-C® Stays in the Body Longer than other Vitamin C


A new clinical study conducted by NBTY, a leading global wellness company, demonstrated that Ester-C®, a patented form of Vitamin C, stays in immune cells longer than regular Vitamin C (ascorbic acid) currently on the market.


New Ester-C(R) Immune CHARGE Gummies

The study, published in SpringerPlus, reports that Ester-C® significantly increases vitamin C concentrations in white blood cells (leukocytes; cell of the immune system) up to 24 hours following a single oral administration of 1000 mg vitamin C. This is the first clinical trial comparing vitamin C retention in leukocytes between Ester-C® and ascorbic acid in both male and female nonsmokers.

In this double-blind, placebo-controlled, crossover trial, thirty healthy subjects aged 18–60 years were randomized to receive placebo (0 mg vitamin C), ascorbic acid (1000 mg vitamin C), and Ester-C® (1000 mg vitamin C), each preceded by a 7-day washout period. The Ester-C® group had a significantly higher mean concentration change in leukocyte vitamin C, while there was no change in the ascorbic acid or placebo groups. The Ester-C® group also had a significantly higher percent change in leukocyte vitamin C compared to ascorbic acid at 8- and 24-hrs after the oral consumption.

Dr. Susan Hazels Mitmesser, author of the study and Sr. Director of Nutrition & Scientific Affairs at NBTY, said, “This study is a great example of the commitment NBTY has to scientific diligence around our product innovations. As new ingredients and areas of research emerge, our scientific leadership will continue to be a priority and a differentiator in the scientific community and the supplement market with NBTY products leading the way.”

“Ester-C is the only product of its kind on the market, and customers can easily find it by the ’24-Hour Immune Support’ call out on the label,” added John Frame, Vice President of Marketing for Ester-C®.

“This product has been clinically studied to stay in the white blood cells longer than regular Vitamin-C — a distinct advantage to anyone looking to nutritionally support their immune system all day long.”

About Ester-C®
Ester-C® is a unique, patented form of vitamin C that contains vitamin C metabolites. The vitamin C metabolites in Ester-C® are the same as normal byproducts of the body’s metabolism of vitamin C.  And Ester-C® is an easy form of vitamin C to take because it is nonacidic and gentle on the stomach. For more information on Ester-C®, visit